掀掉腫瘤細胞的假面!原來癌細胞靠這招能奸詐逃過一劫

·2 分鐘 (閱讀時間)


腫瘤細胞呀,掀掉你的假面吧!

要如何藉由先天免疫反應來對抗腫瘤細胞呢?

這說起來簡單,做起來⋯⋯,自有硬碰硬的辦法。效果呢?

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腫瘤細胞呀,掀掉你的假面吧!/原文出處

  1. Barkal AA, Brewer RE, Markovic M, Kowarsky M, Barkal SA, Zaro BW, Krishnan V, Hatakeyama J, Dorigo O, Barkal LJ, Weissman IL. CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy. Nature. 2019 Aug;572(7769):392-396. doi: 10.1038/s41586-019-1456-0. Epub 2019 Jul 31.

  2. Panni, R.Z., Linehan, D.C. & DeNardo, D.G. Targeting tumor-infiltrating macrophages to combat cancer. Immunotherapy 5, 1075-1087 (2013).

  3. Majeti, R. et al. CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell 138, 286-299 (2009).

  4. Gordon, S.R. et al. PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity. Nature 545, 495-499 (2017).

  5. Barkal, A.A. et al. Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy. Nat Immunol 19, 76-84 (2018).

  6. Advani, R. et al. CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin's Lymphoma. N Engl J Med 379, 1711-1721 (2018).

  7. Willingham, S.B. et al. The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci U S A 109, 6662-6667 (2012).

  8. Barkal, A.A. et al. CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy. Nature 572, 392-396 (2019).


原文引自:癌細胞奸詐躲過免疫系統!免疫抗癌新突破「掀掉腫瘤細胞的假面」



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